• Target：
• TORC3

• Fields：
• >>Human T-cell leukemia virus 1 infection

• Gene Name：
• CRTC3

• Protein Name：
• CREB-regulated transcription coactivator 3

• Human Gene Id：
• 64784

• Human Swiss Prot No：
• Q6UUV7

• Mouse Swiss Prot No：
• Q91X84

• Immunogen：
• Purified recombinant fragment of human TORC3 expressed in E. Coli.

• Specificity：
• TORC3 Monoclonal Antibody detects endogenous levels of TORC3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CRTC3;TORC3;CREB-regulated transcription coactivator 3;Transducer of regulated cAMP response element-binding protein 3;TORC-3;Transducer of CREB protein 3

• Molecular Weight(Da)：
• 67kD

• References：
• 1. Mod Pathol. 2009 Dec;22(12):1575-81.
  2. Genes Chromosomes Cancer. 2008 Mar;47(3):203-6.

• Background：
• This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012],

• Function：
• function:Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).,similarity:Belongs to the TORC family.,subcellular location:Appears to be mainly nuclear.,subunit:Binding, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 enhances recruitment of TAF4 to the promoter. 'Arg-314' in the bZIP domai

• Subcellular Location：
• Nucleus . Cytoplasm . Appears to be mainly nuclear (PubMed:15454081). Translocates to the nucleus following adenylyl cyclase or MAP kinase activation (PubMed:30611118). .

• Expression：
• Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.

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