• Target：
• CD80

• Fields：
• >>Cell adhesion molecules;>>Toll-like receptor signaling pathway;>>Intestinal immune network for IgA production;>>Type I diabetes mellitus;>>Autoimmune thyroid disease;>>Systemic lupus erythematosus;>>Rheumatoid arthritis;>>Allograft rejection;>>Graft-versus-host disease;>>Viral myocarditis

• Gene Name：
• CD80

• Protein Name：
• T-lymphocyte activation antigen CD80

• Human Gene Id：
• 941

• Human Swiss Prot No：
• P33681

• Mouse Swiss Prot No：
• Q00609

• Immunogen：
• Purified recombinant fragment of CD80 expressed in E. Coli.

• Specificity：
• CD80 Monoclonal Antibody detects endogenous levels of CD80 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CD80;CD28LG;CD28LG1;LAB7;T-lymphocyte activation antigen CD80;Activation B7-1 antigen;BB1;CTLA-4 counter-receptor B7.1;B7;CD antigen CD80

• References：
• 1. Transplant Proc. 2008 Oct;40(8):2729-33.
  2. Nat Med. 2007 Dec;13(12):1440-9.

• Background：
• The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011],

• Function：
• function:Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.,tissue specificity:Expressed on activated B-cells, macrophages and dendritic cells.,

• Subcellular Location：
• Membrane; Single-pass type I membrane protein.

• Expression：
• Expressed on activated B-cells, macrophages and dendritic cells.

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