ApoA-IV Monoclonal Antibody

    • Catalog No.：YM0032
    • Applications：WB;ELISA
    • Reactivity：Human
      • Target：
      • ApoA-IV
      • Fields：
      • >>Fat digestion and absorption;>>Vitamin digestion and absorption;>>Cholesterol metabolism;>>Lipid and atherosclerosis
      • Gene Name：
      • APOA4
      • Protein Name：
      • Apolipoprotein A-IV
      • Human Gene Id：
      • 337
      • Human Swiss Prot No：
      • P06727
      • Mouse Swiss Prot No：
      • P06728
      • Immunogen：
      • Purified recombinant fragment of ApoA-IV (aa21-396) expressed in E. Coli.
      • Specificity：
      • ApoA-IV Monoclonal Antibody detects endogenous levels of ApoA-IV protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Monoclonal, Mouse
      • Dilution：
      • WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
      • Purification：
      • Affinity purification
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • APOA4;Apolipoprotein A-IV;Apo-AIV;ApoA-IV;Apolipoprotein A4
      • Molecular Weight(Da)：
      • 45kD
      • References：
      • 1. J Biol Chem. 2006 Feb 10;281(6):3560-8.
        2. Clin Chim Acta. 2008 Feb;388(1-2):78-83.
      • Background：
      • Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008],
      • Function：
      • domain:Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.,function:May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.,online information:The Singapore human mutation and polymorphism database,polymorphism:Eight alleles have been characterized (APOA-IV*0 to APOA-IV*7). APOA-IV*1 is the major allele (90%), APOA-IV*2 is also common (8%), the others are rare alleles.,similarity:Belongs to the apolipoprotein A1/A4/E family.,tissue
      • Subcellular Location：
      • Secreted.
      • Expression：
      • Synthesized primarily in the intestine and secreted in plasma.
      • Products Images
      • Western Blot analysis using ApoA-IV Monoclonal Antibody against truncated APOA4-His recombinant protein (1),truncated APOA4(aa21-396)-hIgGFc transfected CHO-K1 cell lysate(2),human serum (3) and human plasma (4).

      Attributes

      • Code：
      • YM0032
      • Size
      • 50μL / 100μL / 200μL
      • Price$：
      • 210 / 350 / 600
      • Delivery：
      • 2024-11-30
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