• Target：
• TRM6

• Gene Name：
• TRMT6 KIAA1153 TRM6 CGI-09

• Protein Name：
• TRM6

• Human Gene Id：
• 51605

• Human Swiss Prot No：
• Q9UJA5

• Mouse Gene Id：
• 66926

• Mouse Swiss Prot No：
• Q8CE96

• Immunogen：
• Synthesized peptide derived from human TRM6 AA range: 175-225

• Specificity：
• This antibody detects endogenous levels of TRM6 at Human/Mouse

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 55kD

• Background：
• This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

• Function：
• function:Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the TRM6/GCD10 family.,subunit:tRNA (adenine-N(1)-)-methyltransferase is a heterodimer of trm6 and trm61.,tissue specificity:Expressed in brain, liver, testis and ovary.,

• Subcellular Location：
• Nucleus .

• Expression：
• Expressed in brain, liver, testis and ovary.

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