TWF1 rabbit pAb
- Catalog No.:YT6671
- Applications:WB
- Reactivity:Human;Mouse;Rat
- Target:
- TWF1
- Gene Name:
- TWF1 PTK9
- Protein Name:
- TWF1
- Human Gene Id:
- 5756
- Human Swiss Prot No:
- Q12792
- Mouse Gene Id:
- 19230
- Mouse Swiss Prot No:
- Q91YR1
- Rat Gene Id:
- 315265
- Rat Swiss Prot No:
- Q5RJR2
- Immunogen:
- Synthesized peptide derived from human TWF1 AA range: 179-229
- Specificity:
- This antibody detects endogenous levels of TWF1 at Human/Mouse/Rat
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 39kD
- Background:
- This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1. [provided by RefSeq, Jul 2008],
- Function:
- caution:Was originally (PubMed:7507208) thought to have protein tyrosine kinase activity.,function:Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.,online information:Molecular embrace -Issue 73 of August 2006,PTM:Phosphorylated on serine and threonine residues.,similarity:Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.,similarity:Contains 2 ADF-H domains.,subcellular location:Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts.,subunit:Interacts with G-actin; ADP-actin form and capping protein (CP).
- Subcellular Location:
- Cytoplasm. Cytoplasm, cytoskeleton . Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity). .
- Expression:
- Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver.
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- Antibody-FAQs
- Products Images
- Western blot analysis of lysates from MCF-7 cells, primary antibody was diluted at 1:1000, 4°over night