• Target：
• ITM2C

• Gene Name：
• ITM2C BRI3 hucep-14 NPD018 PSEC0047

• Protein Name：
• ITM2C

• Human Gene Id：
• 81618

• Human Swiss Prot No：
• Q9NQX7

• Mouse Gene Id：
• 64294

• Mouse Swiss Prot No：
• Q91VK4

• Rat Gene Id：
• 301575

• Rat Swiss Prot No：
• Q5PQL7

• Immunogen：
• Synthesized peptide derived from human ITM2C AA range: 1-51

• Specificity：
• This antibody detects endogenous levels of ITM2C at Human/Mouse/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 29kD

• Function：
• PTM:Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C.,similarity:Belongs to the ITM2 family.,similarity:Contains 1 BRICHOS domain.,subunit:Interacts with BACE1.,tissue specificity:High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs.,

• Subcellular Location：
• Lysosome membrane ; Single-pass type II membrane protein . Cell membrane ; Single-pass type II membrane protein .

• Expression：
• High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs.

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