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- PYDC1 rabbit pAb
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PYDC1 rabbit pAb
- Catalog No.:YT6579
- Applications:IHC;IF
- Reactivity:Human
- Fields:
- >>NOD-like receptor signaling pathway
- Gene Name:
- PYDC1 ASC2 ASCI POP1 PYC1
- Immunogen:
- Synthesized peptide derived from human PYDC1 AA range: 25-75
- Specificity:
- This antibody detects endogenous levels of PYDC1 at Human
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- IHC 1:50-200. IF 1:50-200
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 10kD
- Function:
- function:Associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.,PTM:Phosphorylated.,similarity:Contains 1 DAPIN domain.,subunit:Interacts with PYCARD/ASC.,tissue specificity:Predominantly expressed in monocytes, macrophages and granulocytes.,
- Subcellular Location:
- Cytoplasm . Recruited to specks formed by PYCARD within the cytoplasm. .
- Expression:
- Predominantly expressed in monocytes, macrophages and granulocytes.
![](/uploadfiles/PIC/111feilinaicc.jpg)
- Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).