• Target：
• LCOR

• Gene Name：
• LCOR KIAA1795 MLR2

• Protein Name：
• LCOR

• Human Gene Id：
• 84458

• Human Swiss Prot No：
• Q96JN0

• Mouse Gene Id：
• 212391

• Mouse Swiss Prot No：
• Q6ZPI3

• Immunogen：
• Synthesized peptide derived from human LCOR AA range: 244-294

• Specificity：
• This antibody detects endogenous levels of LCOR at Human/Mouse

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 48kD

• Background：
• LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008],

• Function：
• function:May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR.,similarity:Contains 1 HTH psq-type DNA-binding domain.,subunit:Interacts with ESR1 and ESR2 in the presence of estradiol. Interacts with CTBP1, HDAC3 and HDAC6. Component of a large corepressor complex that contains about 20 proteins, including CTBP1, CTBP2, HDAC1 and HDAC2.,tissue specificity:Ubiquitous.,

• Subcellular Location：
• Nucleus .

• Expression：
• Ubiquitous.

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