• Target：
• CTGF

• Fields：
• >>Apelin signaling pathway;>>Hippo signaling pathway

• Gene Name：
• CTGF CCN2 HCS24 IGFBP8

• Protein Name：
• Connective tissue growth factor (CCN family member 2) (Hypertrophic chondrocyte-specific protein 24) (Insulin-like growth factor-binding protein 8) (IBP-8) (IGF-binding protein 8) (IGFBP-8)

• Human Gene Id：
• 1490

• Human Swiss Prot No：
• P29279

• Mouse Gene Id：
• 14219

• Mouse Swiss Prot No：
• P29268

• Rat Swiss Prot No：
• Q9R1E9

• Specificity：
• endogenous

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal, rabbit, IgG, Kappa

• Dilution：
• WB 1:500-2000,ELISA 1:5000-20000,IP 1:50-200

• Purification：
• Protein A

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Connective tissue growth factor (CCN family member 2;Hypertrophic chondrocyte-specific protein 24;Insulin-like growth factor-binding protein 8;IBP-8;IGF-binding protein 8;IGFBP-8)

• Molecular Weight(Da)：
• 38kD

• Observed Band(KD)：
• 38kD

• Background：
• The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009],

• Function：
• function:Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.,similarity:Belongs to the CCN family.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 TSP type-1 domain.,similarity:Contains 1 VWFC domain.,subunit:Monomer.,

• Subcellular Location：
• Secreted

• Expression：
• Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.

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