• Target：
• IL-34

• Fields：
• >>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor

• Gene Name：
• IL34

• Protein Name：
• Interleukin-34

• Human Gene Id：
• 146433

• Human Swiss Prot No：
• Q6ZMJ4

• Mouse Swiss Prot No：
• Q8R1R4

• Immunogen：
• Purified recombinant fragment of human IL-34 expressed in E. Coli.

• Specificity：
• IL-34 Monoclonal Antibody detects endogenous levels of IL-34 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• IL34;C16orf77;Interleukin-34;IL-34

• Molecular Weight(Da)：
• 27kD

• References：
• 1. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24.
  2. Lim J, et al. Cell, 2006 May 19.
  3. Lin H, et al. Science, 2008 May 9.

• Background：
• Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008],

• Function：
• function:Cytokine that promotes the differentiation and viability of monocytes and macrophages. Stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Ligand for colony-stimulating factor-1 receptor CSF1R.,similarity:Belongs to the IL-34 family.,subunit:Homodimer.,tissue specificity:Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.,

• Subcellular Location：
• Secreted .

• Expression：
• Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.

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