• Target：
• NPC1L1

• Gene Name：
• NPC1L1

• Protein Name：
• Niemann-Pick C1-like protein 1

• Human Gene Id：
• 29881

• Human Swiss Prot No：
• Q9UHC9

• Mouse Gene Id：
• 237636

• Mouse Swiss Prot No：
• Q6T3U4

• Rat Gene Id：
• 432367

• Rat Swiss Prot No：
• Q6T3U3

• Immunogen：
• Synthesized peptide derived from human C-ternal NPCL1

• Specificity：
• This antibody detects endogenous levels of NPCL1 at Human, Mouse,Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000 IHC 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Niemann-Pick C1-like protein 1

• Molecular Weight(Da)：
• 149kD

• Function：
• Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.

• Subcellular Location：
• Apical cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein (By similarity). According to PubMed:15671032, localizes in a subcellular vesicular compartment rich in RAB5. .

• Expression：
• Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle.

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