STIM2 rabbit pAb

  • Catalog No.：YT8125
  • Applications：IHC;WB
  • Reactivity：Human;Mouse
    • Target：
    • STIM2
    • Gene Name：
    • STIM2 KIAA1482
    • Protein Name：
    • Stromal interaction molecule 2
    • Human Swiss Prot No：
    • Q9P246
    • Mouse Swiss Prot No：
    • P83093
    • Immunogen：
    • Synthesized peptide derived from human C-ternal STIM2
    • Specificity：
    • This antibody detects endogenous levels of STIM2 at Human, Mouse
    • Formulation：
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500-2000 IHC 1:50-200
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Stromal interaction molecule 2
    • Molecular Weight(Da)：
    • 82kD
    • Function：
    • Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.
    • Subcellular Location：
    • Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration.
    • Expression：
    • Expressed in all tissues and tumor cell lines examined.

    Attributes

    • Code：
    • YT8125
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 160 / 280 / 450
    • Delivery：
    • 2024-07-25
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