METL8 rabbit pAb

  • Catalog No.：YT8123
  • Applications：IHC;WB
  • Reactivity：Human;Mouse
    • Target：
    • METTL8
    • Gene Name：
    • METTL8
    • Protein Name：
    • Methyltransferase-like protein 8 (EC 2.1.1.-)
    • Human Swiss Prot No：
    • Q9H825
    • Mouse Swiss Prot No：
    • A2AUU0
    • Immunogen：
    • Synthesized peptide derived from human C-ternal METL8
    • Specificity：
    • This antibody detects endogenous levels of METL8 at Human, Mouse
    • Formulation：
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500-2000 IHC 1:50-200
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Methyltransferase-like protein 8 (EC 2.1.1.-)
    • Molecular Weight(Da)：
    • 32kD
    • Function：
    • Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of mitochondrial tRNA(Ser)(UCN) and tRNA(Thr) . N(3)-methylcytidine methylation modification regulates mitochondrial translation efficiency and is required for activity of the respiratory chain . N(3)-methylcytidine methylation of mitochondrial tRNA(Ser)(UCN) requires the formation of N(6)-dimethylallyladenosine(37) (i6A37) by TRIT1 as prerequisite . May also mediate N(3)-methylcytidine modification of mRNAs . The existence of N(3)-methylcytidine modification on mRNAs is however unclear, and additional evidences are required to confirm the role of the N(3)-methylcytidine-specific mRNA methyltransferase activity of METTL8 in vivo .
    • Subcellular Location：
    • Mitochondrion . Mitochondrial protein: the cytoplasmic or nuclear localization observed by some groups is either the result of an incorrect localization caused by N-terminal tagging that interferes with mitochondrial targeting, or splice isoforms that lack the N-terminal mitochondrial transit sequence. .

    Attributes

    • Code：
    • YT8123
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 160 / 280 / 450
    • Delivery：
    • 2024-11-26
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