TXNIP rabbit pAb

  • Catalog No.：YT8122
  • Applications：IHC;WB
  • Reactivity：Human;Mouse;Rat
    • Target：
    • TXNIP
    • Gene Name：
    • TXNIP VDUP1
    • Protein Name：
    • Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1)
    • Human Swiss Prot No：
    • Q9H3M7
    • Mouse Swiss Prot No：
    • Q8BG60
    • Immunogen：
    • Synthesized peptide derived from human N-ternal TXNIP
    • Specificity：
    • This antibody detects endogenous levels of TXNIP at Human, Mouse,Rat
    • Formulation：
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500-2000 IHC 1:50-200
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1)
    • Molecular Weight(Da)：
    • 43kD
    • Function：
    • May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
    • Subcellular Location：
    • Cytoplasm .

    Attributes

    • Code：
    • YT8122
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 160 / 280 / 450
    • Delivery：
    • 2024-11-26
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