MCLN1 rabbit pAb

  • Catalog No.：YT8120
  • Applications：IHC;WB
  • Reactivity：Human;Mouse
    • Target：
    • MCOLN1
    • Gene Name：
    • MCOLN1 ML4 MSTP080
    • Protein Name：
    • Mucolipin-1 (MG-2) (Mucolipidin)
    • Human Swiss Prot No：
    • Q9GZU1
    • Mouse Swiss Prot No：
    • Q99J21
    • Immunogen：
    • Synthesized peptide derived from human N-ternal MCLN1
    • Specificity：
    • This antibody detects endogenous levels of MCLN1 at Human, Mouse
    • Formulation：
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500-2000 IHC 1:50-200
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Mucolipin-1 (MG-2) (Mucolipidin)
    • Molecular Weight(Da)：
    • 64kD
    • Function：
    • Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy . Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion (By similarity). Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events . By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels .
    • Subcellular Location：
    • Late endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Cell projection, phagocytic cup . Cytoplasmic vesicle, phagosome membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Delivery from the trans-Golgi to lysosomes seems to occur mainly in a direct intracellular manner without intermediate delivery to the plasma membrane (PubMed:16497227). Under normal conditions, restricted to intracellular compartments so that only a very minor proportion is present at the cell membrane (PubMed:12459486, PubMed:18794901, PubMed:28112729, PubMed:29019983). .
    • Expression：
    • Widely expressed in adult and fetal tissues.

    Attributes

    • Code：
    • YT8120
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 160 / 280 / 450
    • Delivery：
    • 2024-07-25
    Order

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