YTDC1 rabbit pAb

  • Catalog No.：YT8115
  • Applications：IHC;WB
  • Reactivity：Human;Rat
    • Target：
    • YTHDC1
    • Gene Name：
    • YTHDC1 KIAA1966 YT521
    • Protein Name：
    • YTH domain-containing protein 1 (Putative splicing factor YT521)
    • Human Swiss Prot No：
    • Q96MU7
    • Immunogen：
    • Synthesized peptide derived from human N-ternal YTDC1
    • Specificity：
    • This antibody detects endogenous levels of YTDC1 at Human,Rat
    • Formulation：
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500-2000 IHC 1:50-200
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • YTH domain-containing protein 1 (Putative splicing factor YT521)
    • Molecular Weight(Da)：
    • 80kD
    • Function：
    • Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs . M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability . Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 . Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing . In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing . May also regulate
    • Subcellular Location：
    • Nucleus . Nucleus speckle . Localizes to a novel subnuclear structure, the YT bodies. .

    Attributes

    • Code：
    • YT8115
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 160 / 280 / 450
    • Delivery：
    • 2024-11-26
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