• Target：
• YTHDF3

• Gene Name：
• YTHDF3

• Protein Name：
• YTH domain family protein 3

• Human Gene Id：
• 253943

• Human Swiss Prot No：
• Q7Z739

• Mouse Gene Id：
• 229096

• Mouse Swiss Prot No：
• Q8BYK6

• Immunogen：
• Synthesized peptide derived from human N-ternal YTHD3

• Specificity：
• This antibody detects endogenous levels of YTHD3 at Human, Mouse

• Formulation：
• Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000 IHC 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• YTH domain family protein 3

• Molecular Weight(Da)：
• 64kD

• Function：
• Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability . M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing . Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3 . The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation . Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs (By similarity). Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification (By similarity). Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-conta

• Subcellular Location：
• Cytoplasm, cytosol . Cytoplasm, P-body . Cytoplasm, Stress granule .

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