• Target：
• MCM10

• Gene Name：
• MCM10 PRO2249

• Protein Name：
• Protein MCM10 homolog (HsMCM10)

• Human Gene Id：
• 55388

• Human Swiss Prot No：
• Q7L590

• Mouse Gene Id：
• 70024

• Mouse Swiss Prot No：
• Q0VBD2

• Immunogen：
• Synthesized peptide derived from human N-ternal MCM10

• Specificity：
• This antibody detects endogenous levels of MCM10 at Human, Mouse

• Formulation：
• Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000 IHC 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Protein MCM10 homolog (HsMCM10)

• Molecular Weight(Da)：
• 96kD

• Function：
• Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 .

• Subcellular Location：
• Nucleus . Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase. From early to mid-S phase located in discrete nuclear foci. In early S phase, several hundred foci appeared throughout the nucleus. In mid-S phase, the foci appeared at the nuclear periphery and nucleolar regions. In the late S and G phases localized to nucleoli.

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