HMGCL rabbit pAb

  • Catalog No.：YT8089
  • Applications：IHC;WB
  • Reactivity：Human;Mouse;Rat
    • Target：
    • HMGCL
    • Gene Name：
    • HMGCL
    • Protein Name：
    • Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase)
    • Human Gene Id：
    • 3155
    • Human Swiss Prot No：
    • P35914
    • Mouse Swiss Prot No：
    • P38060
    • Immunogen：
    • Synthesized peptide derived from human C-ternal HMGCL
    • Specificity：
    • This antibody detects endogenous levels of HMGCL at Human, Mouse,Rat
    • Formulation：
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500-2000 IHC 1:50-200
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase)
    • Molecular Weight(Da)：
    • 36kD
    • Function：
    • Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.
    • Subcellular Location：
    • Mitochondrion matrix . Peroxisome . Unprocessed form is peroxisomal. .
    • Expression：
    • Highest expression in liver. Expressed in pancreas, kidney, intestine, testis, fibroblasts and lymphoblasts. Very low expression in brain and skeletal muscle. The relative expression of isoform 2 (at mRNA level) is highest in heart (30%), skeletal muscle (22%), and brain (14%).

    Attributes

    • Code：
    • YT8089
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 160 / 280 / 450
    • Delivery：
    • 2024-07-26
    Order

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