LOX12 rabbit pAb

  • Catalog No.：YT8083
  • Applications：IHC;WB
  • Reactivity：Human;Mouse
    • Target：
    • ALOX12
    • Gene Name：
    • ALOX12 LOG12
    • Protein Name：
    • Arachidonate 12-lipoxygenase, 12S-type (12S-LOX) (12S-lipoxygenase) (EC 1.13.11.31) (Platelet-type lipoxygenase 12)
    • Human Gene Id：
    • 239
    • Human Swiss Prot No：
    • P18054
    • Mouse Swiss Prot No：
    • P39655
    • Immunogen：
    • Synthesized peptide derived from human N-ternal LOX12
    • Specificity：
    • This antibody detects endogenous levels of LOX12 at Human, Mouse
    • Formulation：
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500-2000 IHC 1:50-200
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Arachidonate 12-lipoxygenase, 12S-type (12S-LOX) (12S-lipoxygenase) (EC 1.13.11.31) (Platelet-type lipoxygenase 12)
    • Molecular Weight(Da)：
    • 73kD
    • Function：
    • Catalyzes the regio and stereo-specific incorporation of molecular oxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species . Mainly converts arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to the specific bioactive lipid (12S)-hydroperoxyeicosatetraenoate/(12S)-HPETE . Through the production of bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation . It can also catalyze the epoxidation of double bonds of polyunsaturated fatty acids such as (14S)-hydroperoxy-docosahexaenoate/(14S)-HPDHA resulting in the formation of (13S,14S)-epoxy-DHA . Furthermore, it may participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) like resolvin D5 ((7S,17S)-diHPDHA
    • Subcellular Location：
    • Cytoplasm, cytosol. Membrane. Membrane association is stimulated by EGF.
    • Expression：
    • Expressed in vascular smooth muscle cells.

    Attributes

    • Code：
    • YT8083
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 160 / 280 / 450
    • Delivery：
    • 2024-11-26
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