ROR1 rabbit pAb

  • Catalog No.：YT7999
  • Applications：WB
  • Reactivity：Human;Mouse;Rat
    • Target：
    • ROR1
    • Fields：
    • >>Wnt signaling pathway
    • Gene Name：
    • ROR1 NTRKR1
    • Protein Name：
    • ROR1
    • Human Gene Id：
    • 4919
    • Human Swiss Prot No：
    • Q01973
    • Mouse Swiss Prot No：
    • Q9Z139
    • Immunogen：
    • Synthesized peptide derived from human ROR1
    • Specificity：
    • This antibody detects endogenous levels of ROR1 at Human, Mouse,Rat
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500-2000
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Tyrosine-protein kinase transmembrane receptor ROR1 (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1)
    • Observed Band(KD)：
    • 105kD
    • Background：
    • This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012],
    • Function：
    • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,developmental stage:Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.,function:Tyrosine-protein kinase receptor whose role is not yet clear.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.,similarity:Contains 1 FZ (frizzled) domain.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 kringle domain.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed strongly in human heart, lung, and kidney, but weakly in the CNS. The short isoform is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.,
    • Subcellular Location：
    • Membrane ; Single-pass type I membrane protein. Cell projection, axon .
    • Expression：
    • Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.

    Attributes

    • Code：
    • YT7999
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2024-08-09
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