• Target：
• DCNL3

• Gene Name：
• DCUN1D3

• Protein Name：
• DCNL3

• Human Gene Id：
• 123879

• Human Swiss Prot No：
• Q8IWE4

• Mouse Gene Id：
• 233805

• Mouse Swiss Prot No：
• Q8K0V2

• Rat Gene Id：
• 309035

• Rat Swiss Prot No：
• Q4V8B2

• Immunogen：
• Synthesized peptide derived from human DCNL3 AA range: 205-255

• Specificity：
• This antibody detects endogenous levels of DCNL3 at Human/Mouse/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 33kD

• Function：
• similarity:Contains 1 DCUN1 domain.,

• Subcellular Location：
• Cell membrane . Cytoplasm . Nucleus . Cytoplasm, perinuclear region . After UVC treatment, the protein enters to the nucleus gradually (PubMed:18823379). Cell membrane localization is essential for CUL3 neddylation (PubMed:19617556). .

• Expression：
• Tends to be down-regulated in different type of cancers, including lung neuroendocrine carcinoma, thyroid Huerthle cell carcinoma and lung squamous cell carcinoma (PubMed:25349211). Mostly expressed in testis and brain (PubMed:26906416). Highly expressed in liver, bladder and renal normal tissue than their tumor tissue counterparts (PubMed:18823379). Palmitoylation stabilizes DCUN1D3 at the cell membrane (PubMed:19617556).

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