• Target：
• RN213

• Gene Name：
• RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR

• Protein Name：
• RN213

• Human Gene Id：
• 57674

• Human Swiss Prot No：
• Q63HN8

• Mouse Swiss Prot No：
• E9Q555

• Immunogen：
• Synthesized peptide derived from human RN213. AA range:307-407

• Specificity：
• This antibody detects endogenous levels of RN213 at Human/Mouse

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1：50-200. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 573kD

• Background：
• This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011],

• Function：
• disease:A chromosomal aberration involving ALO17 is associated with anaplastic large-cell lymphoma (ALCL). Translocation t(2;17)(p23;q25) with ALK.,sequence caution:Translated as Gln.,similarity:Contains 1 RING-type zinc finger.,

• Subcellular Location：
• Cytoplasm, cytosol . Lipid droplet .

• Expression：
• Widely expressed (at protein level). ; [Isoform 1]: Major isoform detected in all tissues examined. ; [Isoform 2]: Minor isoform with restricted expression.

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