• Target：
• ARY2

• Fields：
• >>Caffeine metabolism;>>Drug metabolism - other enzymes;>>Metabolic pathways;>>Chemical carcinogenesis - DNA adducts

• Gene Name：
• NAT2 AAC2

• Protein Name：
• ARY2

• Human Gene Id：
• 10

• Human Swiss Prot No：
• P11245

• Mouse Gene Id：
• 17961

• Mouse Swiss Prot No：
• P50295

• Rat Gene Id：
• 116632

• Rat Swiss Prot No：
• P50298

• Immunogen：
• Synthesized peptide derived from human ARY2 AA range: 80-130

• Specificity：
• This antibody detects endogenous levels of ARY2 at Human/Mouse/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 32kD

• Background：
• This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.,disease:Genetic variations in NAT2 determine N-acetylation polymorphism by a low or high NAT activity in the liver [MIM:243400]. It has been implicated in the action and toxicity of amine-containing drugs, and in the susceptibility to bladder cancer and systemic lupus erythematosus. This isozyme is responsible for this polymorphism.,function:Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.,online information:NAT alleles,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the arylamine N-acetyltransferase family.,

• Subcellular Location：
• Cytoplasm.

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