CXXC4 rabbit pAb
- Catalog No.:YT7623
- Applications:WB
- Reactivity:Human;Mouse;Rat
- Target:
- CXXC4
- Fields:
- >>Wnt signaling pathway
- Gene Name:
- CXXC4 IDAX
- Protein Name:
- CXXC4
- Human Gene Id:
- 80319
- Human Swiss Prot No:
- Q9H2H0
- Mouse Gene Id:
- 319478
- Mouse Swiss Prot No:
- Q6NXI8
- Rat Gene Id:
- 83824
- Rat Swiss Prot No:
- Q9EQC9
- Immunogen:
- Synthesized peptide derived from human CXXC4 AA range: 15-65
- Specificity:
- This antibody detects endogenous levels of CXXC4 at Human/Mouse/Rat
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 22kD
- Background:
- This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
- Function:
- function:Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1.,similarity:Contains 1 CXXC-type zinc finger.,subunit:Interacts with the PDZ domain of DVL1.,
- Subcellular Location:
- Cytoplasm .
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- Antibody-FAQs
- Products Images
- Western blot analysis of lysates from HEK293 cells, primary antibody was diluted at 1:1000, 4°over night