• Target：
• CYBR1

• Fields：
• >>Mineral absorption

• Gene Name：
• CYBRD1 DCYTB FRRS3

• Protein Name：
• CYBR1

• Human Gene Id：
• 79901

• Human Swiss Prot No：
• Q53TN4

• Mouse Gene Id：
• 73649

• Mouse Swiss Prot No：
• Q925G2

• Rat Gene Id：
• 295669

• Rat Swiss Prot No：
• Q5RKJ2

• Immunogen：
• Synthesized peptide derived from human CYBR1 AA range: 41-91

• Specificity：
• This antibody detects endogenous levels of CYBR1 at Human/Mouse/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 31kD

• Background：
• This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in dietary iron absorption. [provided by RefSeq, Jul 2008],

• Function：
• cofactor:Binds 2 heme groups non-covalently.,disease:Defects in CYBRD1 may be a cause of primary hereditary hemochromatosis (HFE). HFE is an iron-loading disorder characterized by iron accumulation in parenchymal cells. Iron accumulation usually results in tissue damage and causes cirrhosis of the liver, diabetes mellitus, arthropathy, cardiomyopathy, endocrine abnormalities and an increased risk of hepatocellular carcinoma.,function:Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells.,induction:By iron deficiency (at protein level).,similarity:Contains 1 cytochrom

• Subcellular Location：
• Cell membrane ; Multi-pass membrane protein . Apical cell membrane ; Multi-pass membrane protein . Localized at the brush border of duodenal cells. .

• Expression：
• Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium.

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