• Target：
• DOC2B

• Gene Name：
• DOC2B DOC2BL

• Protein Name：
• DOC2B

• Human Gene Id：
• 8447

• Human Swiss Prot No：
• Q14184

• Mouse Gene Id：
• 13447

• Mouse Swiss Prot No：
• P70169

• Rat Gene Id：
• 81820

• Rat Swiss Prot No：
• P70610

• Immunogen：
• Synthesized peptide derived from human DOC2B AA range: 332-382

• Specificity：
• This antibody detects endogenous levels of DOC2B at Human/Mouse/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 45kD

• Background：
• There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells. [provided by RefSeq, Jul 2008],

• Function：
• domain:C2 domain 1 is involved in binding calcium and phospholipids.,function:May be involved in constitutive membrane trafficking including dynein-dependent intracellular vesicle transport. In vitro, binds calcium and phospholipids.,similarity:Contains 2 C2 domains.,subunit:Interacts with cytoplasmic dynein light chain TCTEL1/TCTEX1.,tissue specificity:Widely expressed with highest levels in brain and kidney.,

• Subcellular Location：
• Cytoplasm. Cytoplasmic granule . Cell membrane ; Peripheral membrane protein . Translocates to the plasma membrane in a calcium-dependent manner. .

• Expression：
• Widely expressed with highest levels in brain and kidney. Expressed in pancreatic islet cells (at protein level).

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