• Target：
• LOX15

• Fields：
• >>Arachidonic acid metabolism;>>Linoleic acid metabolism;>>Metabolic pathways;>>Ferroptosis;>>Necroptosis;>>Serotonergic synapse

• Gene Name：
• ALOX15 LOG15

• Protein Name：
• LOX15

• Human Gene Id：
• 246

• Human Swiss Prot No：
• P16050

• Immunogen：
• Synthesized peptide derived from human LOX15 AA range: 156-206

• Specificity：
• This antibody detects endogenous levels of LOX15 at Human

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 73kD

• Function：
• catalytic activity:Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate.,cofactor:Binds 1 iron ion per subunit.,function:Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as well as on linoleic acid.,pathway:Lipid metabolism; leukotriene D4 biosynthesis.,similarity:Belongs to the lipoxygenase family.,similarity:Contains 1 lipoxygenase domain.,similarity:Contains 1 PLAT domain.,

• Subcellular Location：
• Cytoplasm, cytosol . Cell membrane ; Peripheral membrane protein . Lipid droplet . Predominantly cytosolic; becomes enriched at membranes upon calcium binding (By similarity). Translocates from the cytosol to the plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells (By similarity). .

• Expression：
• Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells.

Integration of metabolomics and transcriptomics reveals that Da Chuanxiong Formula improves vascular cognitive impairment via ACSL4/GPX4 mediated ferroptosis JOURNAL OF ETHNOPHARMACOLOGY Tianyu Lou WB Rat brain tissue

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