• Target：
• PUR6

• Fields：
• >>Purine metabolism;>>Metabolic pathways

• Gene Name：
• PAICS ADE2 AIRC PAIS

• Protein Name：
• PUR6

• Human Gene Id：
• 10606

• Human Swiss Prot No：
• P22234

• Mouse Gene Id：
• 67054

• Mouse Swiss Prot No：
• Q9DCL9

• Rat Gene Id：
• 140946

• Rat Swiss Prot No：
• P51583

• Immunogen：
• Synthesized peptide derived from human PUR6 AA range: 107-157

• Specificity：
• This antibody detects endogenous levels of PUR6 at Human/Mouse/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 47kD

• Background：
• This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2).,catalytic activity:ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.,pathway:Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 3/5.,pathway:Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 4/5.,similarity:In the C-terminal section; belongs to the AIR carboxylase family.,similarity:In the N-terminal section; belongs to the SAICAR synthetase family.,subunit:Homooctamer.,

• Subcellular Location：
• cytoplasm,cytosol,cell-cell adherens junction,membrane,extracellular exosome,

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