• Target：
• POMT2

• Fields：
• >>Other types of O-glycan biosynthesis;>>Mannose type O-glycan biosynthesis;>>Metabolic pathways

• Gene Name：
• POMT2

• Protein Name：
• POMT2

• Human Gene Id：
• 29954

• Human Swiss Prot No：
• Q9UKY4

• Mouse Gene Id：
• 217734

• Mouse Swiss Prot No：
• Q8BGQ4

• Immunogen：
• Synthesized peptide derived from human POMT2 AA range: 177-227

• Specificity：
• This antibody detects endogenous levels of POMT2 at Human/Mouse

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 83kD

• Background：
• The protein encoded by this gene is an O-mannosyltransferase that requires interaction with the product of the POMT1 gene for enzymatic function. The encoded protein is found in the membrane of the endoplasmic reticulum. Defects in this gene are a cause of Walker-Warburg syndrome (WWS).[provided by RefSeq, Oct 2008],

• Function：
• catalytic activity:Dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.,cofactor:Magnesium. Manganese and calcium ions suppress enzyme activity.,disease:Defects in POMT2 are a cause of Walker-Warburg syndrome (WWS) [MIM:236670]; also known as hydrocephalus-agyria-retinal dysplasia or HARD syndrome. WWS is an autosomal recessive disorder characterized by cobblestone lissencephaly, hydrocephalus, agyria, retinal displasia, with or without encephalocele. It is often associated with congenital muscular dystrophy and usually lethal within the first few months of life.,function:Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient.,online information:GlycoGene database,pathway:Protein modification; protein gl

• Subcellular Location：
• Endoplasmic reticulum membrane ; Multi-pass membrane protein .

• Expression：
• Highly expressed in testis; detected at low levels in most tissues.

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