• Target：
• TYW2

• Gene Name：
• TRMT12 TRM12 TYW2

• Protein Name：
• TYW2

• Human Gene Id：
• 55039

• Human Swiss Prot No：
• Q53H54

• Mouse Gene Id：
• 68260

• Mouse Swiss Prot No：
• Q8BG71

• Rat Gene Id：
• 314999

• Rat Swiss Prot No：
• Q4V8B8

• Immunogen：
• Synthesized peptide derived from human TYW2 AA range: 11-61

• Specificity：
• This antibody detects endogenous levels of TYW2 at Human/Mouse/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 49kD

• Background：
• Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008],

• Function：
• function:Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.,pathway:tRNA modification; wybutosine-tRNA(Phe) biosynthesis.,sequence caution:Contaminating sequence. Potential poly-A sequence starting in position 371.,sequence caution:Translation N-terminally shortened.,similarity:Belongs to the RNA methyltransferase trmD family. TYW2 subfamily.,

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