• Target：
• QKI

• Gene Name：
• QKI HKQ

• Protein Name：
• QKI

• Human Gene Id：
• 9444

• Human Swiss Prot No：
• Q96PU8

• Mouse Gene Id：
• 19317

• Mouse Swiss Prot No：
• Q9QYS9

• Rat Swiss Prot No：
• Q91XU1

• Immunogen：
• Synthesized peptide derived from human QKI AA range: 198-248

• Specificity：
• This antibody detects endogenous levels of QKI at Human/Mouse/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 38kD

• Background：
• The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014],

• Function：
• disease:Deletion of the QKI gene may play a role in astrocytic tumors.,disease:May play a role in genetic susceptibility to schizophrenia. QKI levels of some isoforms such as isoform 6, are frequently down-regulated in schizophrenic patients.,function:RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor.,PTM:Methylated by PRMT1.,PTM:Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding a

• Subcellular Location：
• Nucleus . Cytoplasm .

• Expression：
• Expressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients.

Involvement of circRNA Regulators MBNL1 and QKI in the Progression of Esophageal Squamous Cell Carcinoma Cancer Control Hai-Feng Wang WB Human 1:2000 KYSE150 cell

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