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- ZMIZ2 rabbit pAb
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ZMIZ2 rabbit pAb
- Catalog No.:YT7293
- Applications:WB
- Reactivity:Human;Mouse
- Gene Name:
- ZMIZ2 KIAA1886 ZIMP7 HRIHFB2007
- Immunogen:
- Synthesized peptide derived from human ZMIZ2 AA range: 512-562
- Specificity:
- This antibody detects endogenous levels of ZMIZ2 at Human/Mouse
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 101kD
- Background:
- ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]).[supplied by OMIM, May 2010],
- Function:
- domain:The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein.,function:Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.,similarity:Contains 1 SP-RING-type zinc finger.,subcellular location:Detected at replication foci throughout S phase.,subunit:Interacts with AR, SMARCA4/BRG1 and SMARCE1/BAF57. Interaction with either SMARCA4 and SMARCE1 enhances AR-mediated transcription.,tissue specificity:Expressed most abundantly in testis with lower levels in heart, brain, pancreas, prostate and ovary.,
- Subcellular Location:
- Nucleus . Detected at replication foci throughout S phase.
- Expression:
- Expressed most abundantly in testis with lower levels in heart, brain, pancreas, prostate and ovary.
- Western blot analysis of lysates from VEC cells, primary antibody was diluted at 1:1000, 4°over night