• Target：
• ATG12

• Fields：
• >>FoxO signaling pathway;>>Autophagy - other;>>Autophagy - animal;>>NOD-like receptor signaling pathway;>>RIG-I-like receptor signaling pathway;>>Shigellosis

• Gene Name：
• ATG12 APG12 APG12L

• Protein Name：
• ATG12

• Human Gene Id：
• 9140

• Human Swiss Prot No：
• O94817

• Mouse Gene Id：
• 67526

• Mouse Swiss Prot No：
• Q9CQY1

• Rat Gene Id：
• 361321

• Rat Swiss Prot No：
• Q2TBJ5

• Immunogen：
• Synthesized peptide derived from human ATG12 AA range: 80-130

• Specificity：
• This antibody detects endogenous levels of ATG12 at Human/Mouse/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 15kD

• Background：
• Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 [PubMed 9852036]).[supplied by OMIM, Mar 2008],

• Function：
• function:Required for autophagy.,similarity:Belongs to the ATG12 family.,subunit:Conjugated to ATG5.,tissue specificity:Ubiquitous.,

• Subcellular Location：
• Cytoplasm . Preautophagosomal structure membrane ; Peripheral membrane protein . TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane.

• Expression：
• Ubiquitous.

PTH1-34 promotes osteoblast formation through Beclin1-dependent autophagic activation. JOURNAL OF BONE AND MINERAL METABOLISM J Bone Miner Metab. 2021 Jul;39(4):572-582 WB Mouse MC3T3-E1 cell

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