• Target：
• NLRC4

• Fields：
• >>NOD-like receptor signaling pathway;>>Shigellosis;>>Salmonella infection;>>Legionellosis;>>Yersinia infection

• Gene Name：
• NLRC4 CARD12 CLAN CLAN1 IPAF UNQ6189/PRO20215

• Protein Name：
• NLRC4

• Human Gene Id：
• 58484

• Human Swiss Prot No：
• Q9NPP4

• Mouse Gene Id：
• 268973

• Mouse Swiss Prot No：
• Q3UP24

• Rat Swiss Prot No：
• F1M649

• Immunogen：
• Synthesized peptide derived from human NLRC4 AA range: 481-531

• Specificity：
• This antibody detects endogenous levels of NLRC4 at Human/Mouse/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 113kD

• Background：
• This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014],

• Function：
• function:Plays a role in the promotion of apoptosis.,similarity:Contains 1 CARD domain.,similarity:Contains 1 NACHT domain.,similarity:Contains 14 LRR (leucine-rich) repeats.,subcellular location:Cytoplasmic filaments.,subunit:Self-associates and binds to ASC, pro-caspase-1, NOD2, BCL10 and NALP1 (NAC) by CARD-CARD interaction.,tissue specificity:Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.,

• Subcellular Location：
• Cytoplasm . Cytoplasm, cytosol . Inflammasome .

• Expression：
• Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.

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