NLRC4 rabbit pAb
- Catalog No.:YT7243
- Applications:WB
- Reactivity:Human;Mouse;Rat
- Target:
- NLRC4
- Fields:
- >>NOD-like receptor signaling pathway;>>Shigellosis;>>Salmonella infection;>>Legionellosis;>>Yersinia infection
- Gene Name:
- NLRC4 CARD12 CLAN CLAN1 IPAF UNQ6189/PRO20215
- Protein Name:
- NLRC4
- Human Gene Id:
- 58484
- Human Swiss Prot No:
- Q9NPP4
- Mouse Gene Id:
- 268973
- Mouse Swiss Prot No:
- Q3UP24
- Rat Swiss Prot No:
- F1M649
- Immunogen:
- Synthesized peptide derived from human NLRC4 AA range: 481-531
- Specificity:
- This antibody detects endogenous levels of NLRC4 at Human/Mouse/Rat
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 113kD
- Background:
- This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014],
- Function:
- function:Plays a role in the promotion of apoptosis.,similarity:Contains 1 CARD domain.,similarity:Contains 1 NACHT domain.,similarity:Contains 14 LRR (leucine-rich) repeats.,subcellular location:Cytoplasmic filaments.,subunit:Self-associates and binds to ASC, pro-caspase-1, NOD2, BCL10 and NALP1 (NAC) by CARD-CARD interaction.,tissue specificity:Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.,
- Subcellular Location:
- Cytoplasm . Cytoplasm, cytosol . Inflammasome .
- Expression:
- Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.
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- Antibody-FAQs
- Products Images
- Glucose-driven transformable complex eliminates biofilm and alleviates inflamm-aging for diabetic periodontitis therapy. Bin Liu WB Mouse 1:1500 RAW264.7 cell
- Western blot analysis of lysates from KB cells, primary antibody was diluted at 1:1000, 4°over night