ERLN2 rabbit pAb
- Catalog No.:YT7212
- Applications:WB
- Reactivity:Human;Mouse;Rat
- Target:
- ERLN2
- Gene Name:
- ERLIN2 C8orf2 SPFH2 UNQ2441/PRO5003/PRO9924
- Protein Name:
- ERLN2
- Human Gene Id:
- 11160
- Human Swiss Prot No:
- O94905
- Mouse Gene Id:
- 244373
- Mouse Swiss Prot No:
- Q8BFZ9
- Rat Gene Id:
- 290823
- Rat Swiss Prot No:
- B5DEH2
- Immunogen:
- Synthesized peptide derived from human ERLN2 AA range: 239-289
- Specificity:
- This antibody detects endogenous levels of ERLN2 at Human/Mouse/Rat
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 37kD
- Background:
- This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012],
- Function:
- function:Plays an important role in the early steps of the endoplasmic reticulum-associated degradation (ERAD) pathway. Involved in ITPR1 degradation by the ERAD pathway.,similarity:Belongs to the band 7/mec-2 family.,subcellular location:Associated with lipid raft-like domains of the endoplasmic reticulum membrane.,subunit:Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination.,tissue specificity:Ubiquitous.,
- Subcellular Location:
- Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
- Expression:
- Ubiquitous.
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- Antibody-FAQs
- Products Images
- Western blot analysis of lysates from Hela cells, primary antibody was diluted at 1:1000, 4°over night