• Target：
• S27A1

• Fields：
• >>PPAR signaling pathway;>>Insulin resistance;>>Fat digestion and absorption

• Gene Name：
• SLC27A1 ACSVL5 FATP1

• Protein Name：
• S27A1

• Human Gene Id：
• 376497

• Human Swiss Prot No：
• Q6PCB7

• Mouse Gene Id：
• 26457

• Mouse Swiss Prot No：
• Q60714

• Rat Swiss Prot No：
• P97849

• Immunogen：
• Synthesized peptide derived from human S27A1 AA range: 115-165

• Specificity：
• This antibody detects endogenous levels of S27A1 at Human/Mouse/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 71kD

• Function：
• function:Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of Fatp1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids.,miscellaneous:FATP1-mediated fatty acid uptake is associated to paramaters r

• Subcellular Location：
• Cell membrane ; Single-pass membrane protein . Endomembrane system ; Single-pass membrane protein . Cytoplasm . Plasma membrane and intracellular membranes, at least in adipocytes. In adipocytes, but not myocytes, insulin via the mTORC1 signaling pathway induces a rapid translocation of SLC27A1 from intracellular compartments to the plasma membrane, paralleled by increased LCFA uptake. Insulin-dependent translocation from the cytoplasm to the cell membrane is regulated by EPRS1. Predominantly cytoplasmic in myocytes. .

• Expression：
• Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver. Expressed in brain gray matter (PubMed:21395585).

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