• Target：
• CNOT6

• Fields：
• >>RNA degradation

• Gene Name：
• CNOT6 CCR4 KIAA1194

• Protein Name：
• CNOT6

• Human Gene Id：
• 57472

• Human Swiss Prot No：
• Q9ULM6

• Mouse Gene Id：
• 104625

• Mouse Swiss Prot No：
• Q8K3P5

• Rat Gene Id：
• 287249

• Rat Swiss Prot No：
• Q6AXU9

• Immunogen：
• Synthesized peptide derived from human CNOT6 AA range: 293-343

• Specificity：
• This antibody detects endogenous levels of CNOT6 at Human/Mouse/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 61kD

• Background：
• This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014],

• Function：
• cofactor:Magnesium.,function:Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. Has 3'-5' RNase activity. The CCR4-NOT complex functions as general transcription regulation complex.,similarity:Belongs to the CCR4/nocturin family.,similarity:Contains 3 LRR (leucine-rich) repeats.,subunit:Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. Interacts with UNR.,

• Subcellular Location：
• Cytoplasm . Nucleus . Predominantly cytoplasmic. .

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