• Target：
• SAC2

• Fields：
• >>Inositol phosphate metabolism;>>Metabolic pathways;>>Phosphatidylinositol signaling system

• Gene Name：
• INPP5F KIAA0966 SAC2 MSTP007 MSTP047

• Protein Name：
• SAC2

• Human Gene Id：
• 22876

• Human Swiss Prot No：
• Q9Y2H2

• Mouse Gene Id：
• 101490

• Mouse Swiss Prot No：
• Q8CDA1

• Immunogen：
• Synthesized peptide derived from human SAC2 AA range: 1006-1056

• Specificity：
• This antibody detects endogenous levels of SAC2 at Human/Mouse

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 125kD

• Background：
• The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011],

• Function：
• function:Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-triphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation.,miscellaneous:Inositol polyphosphate 5-phosphatases usually have 2 conserved motifs that are essential for 5-phosphatase activity. However, INPP5F does not contain such motifs, and phosphatase activity seems to exist in the SAC domain, suggesting a new type of phosphoinositide 5-phosphatase.,similarity:Contains 1 SAC domain.,tissue specificity:Ubiquitous.,

• Subcellular Location：
• Membrane, clathrin-coated pit . Early endosome . Recycling endosome . Also found on macropinosomes. .

• Expression：
• Ubiquitous (PubMed:11274189). Highly expressed in brain (PubMed:26203138).

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