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- SAC2 rabbit pAb
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SAC2 rabbit pAb
- Catalog No.:YT7095
- Applications:WB
- Reactivity:Human;Mouse
- Fields:
- >>Inositol phosphate metabolism;>>Metabolic pathways;>>Phosphatidylinositol signaling system
- Gene Name:
- INPP5F KIAA0966 SAC2 MSTP007 MSTP047
- Immunogen:
- Synthesized peptide derived from human SAC2 AA range: 1006-1056
- Specificity:
- This antibody detects endogenous levels of SAC2 at Human/Mouse
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 125kD
- Background:
- The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011],
- Function:
- function:Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-triphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation.,miscellaneous:Inositol polyphosphate 5-phosphatases usually have 2 conserved motifs that are essential for 5-phosphatase activity. However, INPP5F does not contain such motifs, and phosphatase activity seems to exist in the SAC domain, suggesting a new type of phosphoinositide 5-phosphatase.,similarity:Contains 1 SAC domain.,tissue specificity:Ubiquitous.,
- Subcellular Location:
- Membrane, clathrin-coated pit . Early endosome . Recycling endosome . Also found on macropinosomes. .
- Expression:
- Ubiquitous (PubMed:11274189). Highly expressed in brain (PubMed:26203138).
![](/uploadfiles/PIC/YT7095wb-2019.jpg)
- Western blot analysis of lysates from DU145 cells, primary antibody was diluted at 1:1000, 4°over night