• Target：
• CHMP6

• Fields：
• >>Viral life cycle - HIV-1;>>Endocytosis;>>Necroptosis

• Gene Name：
• CHMP6 VPS20

• Protein Name：
• CHMP6

• Human Gene Id：
• 79643

• Human Swiss Prot No：
• Q96FZ7

• Mouse Gene Id：
• 208092

• Mouse Swiss Prot No：
• P0C0A3

• Immunogen：
• Synthesized peptide derived from human CHMP6 AA range: 87-137

• Specificity：
• This antibody detects endogenous levels of CHMP6 at Human/Mouse

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 22kD

• Background：
• This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein family. Proteins in this family are part of the ESCRT-III (endosomal sorting complex required for transport III) which degrades surface receptors, and in biosynthesis of endosomes. [provided by RefSeq, Mar 2012],

• Function：
• domain:The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components.,function:Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB path

• Subcellular Location：
• Endomembrane system. Endosome membrane; Lipid-anchor. Late endosome membrane . Membrane ; Lipid-anchor . Localizes to endosomal membranes.

• Expression：
• Ubiquitously expressed.

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