PSD10 rabbit pAb
- Catalog No.:YT6997
- Applications:WB;ELISA;IHC
- Reactivity:Human;Mouse;Rat
- Target:
- PSD10
- Gene Name:
- PSMD10
- Protein Name:
- PSD10
- Human Gene Id:
- 5716
- Human Swiss Prot No:
- O75832
- Mouse Swiss Prot No:
- Q9Z2X2
- Rat Gene Id:
- 116722
- Rat Swiss Prot No:
- Q9Z2X3
- Immunogen:
- Synthesized peptide derived from human PSD10 AA range: 86-136
- Specificity:
- This antibody detects endogenous levels of PSD10 at Human/Mouse/Rat
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 25kD
- Background:
- This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011],
- Function:
- function:Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.,similarity:Contains 7 ANK repeats.,subunit:Component of the PA700 complex.,
- Subcellular Location:
- Cytoplasm . Nucleus .
- Expression:
- Tends to be up-regulated in cancer cells with RAS mutations, including lung cancers and adenocarconimas (at protein level).
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- Antibody-FAQs
- Products Images
- Western blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4°over night
- Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).