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- RPIA rabbit pAb
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RPIA rabbit pAb
- Catalog No.:YT6982
- Applications:WB
- Reactivity:Human;Mouse
- Fields:
- >>Pentose phosphate pathway;>>Metabolic pathways;>>Carbon metabolism;>>Biosynthesis of amino acids
- Immunogen:
- Synthesized peptide derived from human RPIA AA range: 256-306
- Specificity:
- This antibody detects endogenous levels of RPIA at Human/Mouse
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 34kD
- Background:
- The protein encoded by this gene is an enzyme, which catalyzes the reversible conversion between ribose-5-phosphate and ribulose-5-phosphate in the pentose-phosphate pathway. This gene is highly conserved in most organisms. The enzyme plays an essential role in the carbohydrate metabolism. Mutations in this gene cause ribose 5-phosphate isomerase deficiency. A pseudogene is found on chromosome 18. [provided by RefSeq, Mar 2010],
- Function:
- catalytic activity:D-ribose 5-phosphate = D-ribulose 5-phosphate.,disease:Defects in RPIA are the cause of ribose 5-phosphate isomerase deficiency [MIM:608611]. A patient has been described with a deficiency of ribose 5-phosphate isomerase who presented with leukoencephalopathy and peripheral neuropathy. Proton magnetic resonance spectroscopy of the brain revealed a highly elevated level of the polyols ribitol and D-arabitol, which were subsequently also found in high concentrations in body fluids. Deficient activity of RPIA, one of the pentose phosphate pathway enzymes, has been demonstrated in fibroblasts.,pathway:Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.,similarity:Belongs to the ribose 5-phosphate isomerase family.,
- Subcellular Location:
- cytosol,integral component of membrane,intracellular membrane-bounded organelle,
![](/uploadfiles/PIC/YT6982wb-2019.jpg)
- Western blot analysis of lysates from HuvEc cells, primary antibody was diluted at 1:1000, 4°over night