C1GLT rabbit pAb
- Catalog No.:YT6838
- Applications:WB
- Reactivity:Human;Mouse;Rat
- Target:
- C1GLT
- Fields:
- >>Mucin type O-glycan biosynthesis;>>Other types of O-glycan biosynthesis;>>Metabolic pathways
- Gene Name:
- C1GALT1
- Protein Name:
- C1GLT
- Human Gene Id:
- 56913
- Human Swiss Prot No:
- Q9NS00
- Mouse Gene Id:
- 94192
- Mouse Swiss Prot No:
- Q9JJ06
- Rat Gene Id:
- 65044
- Rat Swiss Prot No:
- Q9JJ05
- Immunogen:
- Synthesized peptide derived from human C1GLT AA range: 102-152
- Specificity:
- This antibody detects endogenous levels of C1GLT at Human/Mouse/Rat
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 40kD
- Background:
- The protein encoded by this gene generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R. Core 1 is a precursor for many extended mucin-type O-glycans on cell surface and secreted glycoproteins. Studies in mice suggest that this gene plays a key role in thrombopoiesis and kidney homeostasis.[provided by RefSeq, Sep 2010],
- Function:
- catalytic activity:UDP-galactose + glycoprotein N-acetyl-D-galactosamine = UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine.,cofactor:Magnesium.,disease:Defects in C1GALT1 may be a cause of susceptibility to IgA nephropathy (IgAN). IgAN is the most common primary glomerulonephritis, which is partly due to aberrant or incomplete galactosylation of IgA1 molecules.,function:Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.,online information:Core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.,
- Subcellular Location:
- Membrane ; Single-pass type II membrane protein .
- Expression:
- Widely expressed. Highly expressed in kidney, heart, placenta and liver.
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- Antibody-FAQs
- Products Images
- Western blot analysis of lysates from MCF-7 cells, primary antibody was diluted at 1:1000, 4°over night