NPC2 rabbit pAb

    • Catalog No.：YT6803
    • Applications：WB
    • Reactivity：Human;Mouse
      • Target：
      • NPC2
      • Fields：
      • >>Lysosome;>>Cholesterol metabolism
      • Gene Name：
      • NPC2 HE1
      • Protein Name：
      • NPC2
      • Human Swiss Prot No：
      • P61916
      • Mouse Swiss Prot No：
      • Q9Z0J0
      • Immunogen：
      • Synthesized peptide derived from human NPC2 AA range: 9-59
      • Specificity：
      • This antibody detects endogenous levels of NPC2 at Human/Mouse
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Polyclonal, Rabbit,IgG
      • Dilution：
      • WB 1：500-2000
      • Purification：
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration：
      • 1 mg/ml
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Molecular Weight(Da)：
      • 17kD
      • Background：
      • This gene encodes a protein containing a lipid recognition domain. The encoded protein may function in regulating the transport of cholesterol through the late endosomal/lysosomal system. Mutations in this gene have been associated with Niemann-Pick disease, type C2 and frontal lobe atrophy. [provided by RefSeq, Jul 2008],
      • Function：
      • disease:Defects in NPC2 are the cause of Niemann-Pick disease type C2 (NPC2) [MIM:607625]. NPC2 is a fatal autosomal recessive hereditary disease characterized by the accumulation of low-density lipoprotein-derived cholesterol in lysosomes.,function:May be involved in the regulation of the lipid composition of sperm membranes during the maturation in the epididymis.,similarity:Belongs to the NPC2 family.,tissue specificity:Epididymis.,
      • Subcellular Location：
      • Secreted . Endoplasmic reticulum . Lysosome . Interaction with cell-surface M6PR mediates endocytosis and targeting to lysosomes. .
      • Expression：
      • Detected in gallbladder bile (PubMed:21315718). Detected in fibroblasts, kidney, liver, spleen, small intestine, placenta and testis (at protein level) (PubMed:11125141). Epididymis.
      • Products Images
      • Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°over night

      Attributes

      • Code：
      • YT6803
      • Size
      • 40μL / 100μL / 200μL
      • Price$：
      • 150 / 280 / 450
      • Delivery：
      • 2024-09-04
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