MLXPL rabbit pAb
- Catalog No.:YT6797
- Applications:WB;ELISA;IHC
- Reactivity:Human;Mouse;Rat
- Target:
- MLXPL
- Fields:
- >>Insulin resistance;>>Non-alcoholic fatty liver disease
- Gene Name:
- MLXIPL BHLHD14 MIO WBSCR14
- Protein Name:
- MLXPL
- Human Gene Id:
- 51085
- Human Swiss Prot No:
- Q9NP71
- Mouse Gene Id:
- 58805
- Mouse Swiss Prot No:
- Q99MZ3
- Rat Gene Id:
- 171078
- Rat Swiss Prot No:
- Q8VIP2
- Immunogen:
- Synthesized peptide derived from human MLXPL AA range: 303-353
- Specificity:
- This antibody detects endogenous levels of MLXPL at Human/Mouse/Rat
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 94kD
- Background:
- This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
- Function:
- disease:Haploinsufficiency of WBSCR14 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) [MIM:194050]. WBS is a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,function:Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Binds DNA as a heterodimer with TCFL4/MLX.,tissue specificity:Expressed in liver, heart, kidney, cerebellum and intestinal tissues.,
- Subcellular Location:
- Nucleus.
- Expression:
- Expressed in liver, heart, kidney, cerebellum and intestinal tissues.
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- Antibody-FAQs
- Products Images
- Western blot analysis of lysates from Hela cells, primary antibody was diluted at 1:1000, 4°over night
- Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).