LOXL4 rabbit pAb
- Catalog No.:YT6756
- Applications:WB;IHC
- Reactivity:Human;Mouse
- Target:
- LOXL4
- Gene Name:
- LOXL4 LOXC
- Protein Name:
- LOXL4
- Human Gene Id:
- 84171
- Human Swiss Prot No:
- Q96JB6
- Mouse Gene Id:
- 67573
- Mouse Swiss Prot No:
- Q924C6
- Immunogen:
- Synthesized peptide derived from human LOXL4 AA range: 39-89
- Specificity:
- This antibody detects endogenous levels of LOXL4 at Human/Mouse
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000;IHC 1:50-300
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 83kD
- Background:
- This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008],
- Function:
- cofactor:Contains 1 lysine tyrosylquinone.,cofactor:Copper.,function:May modulate the formation of a collagenous extracellular matrix.,PTM:The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.,similarity:Belongs to the lysyl oxidase family.,similarity:Contains 4 SRCR domains.,tissue specificity:Expressed in many tissues, the highest levels among the tissues studied being in the skeletal muscle, testis and pancreas. Expressed in cartilage.,
- Subcellular Location:
- Secreted, extracellular space .
- Expression:
- Expressed in many tissues, the highest levels among the tissues studied being in the skeletal muscle, testis and pancreas. Expressed in cartilage.
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- Antibody-FAQs
- Products Images
- Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°over night
- Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).