NEUR3 rabbit pAb
- Catalog No.:YT6735
- Applications:WB
- Reactivity:Human;Mouse;Rat
- Target:
- NEUR3
- Fields:
- >>Other glycan degradation;>>Sphingolipid metabolism;>>Metabolic pathways
- Gene Name:
- NEU3
- Protein Name:
- NEUR3
- Human Swiss Prot No:
- Q9UQ49
- Mouse Gene Id:
- 50877
- Mouse Swiss Prot No:
- Q9JMH7
- Rat Gene Id:
- 117185
- Rat Swiss Prot No:
- Q99PW5
- Immunogen:
- Synthesized peptide derived from human NEUR3 AA range: 132-182
- Specificity:
- This antibody detects endogenous levels of NEUR3 at Human/Mouse/Rat
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 47kD
- Background:
- This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008],
- Function:
- catalytic activity:Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.,function:Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates.,similarity:Belongs to the glycosyl hydrolase 33 family.,similarity:Contains 3 BNR repeats.,tissue specificity:Highly expressed in skeletal muscle, testis, adrenal gland and thymus, followed by pancreas, liver, heart and thymus. Weakly expressed in kidney, placenta, brain and lung.,
- Subcellular Location:
- Cell membrane ; Peripheral membrane protein . Membrane, caveola . Early endosome membrane ; Peripheral membrane protein . Recycling endosome membrane ; Peripheral membrane protein . Lysosome membrane ; Peripheral membrane protein . Associates with the external leaflet of the plasma membrane (By similarity). S-acylated NEU3 likely spans the lipid bilayer with a portion of C-terminus exposed to the cytosol and the catalytic region facing the extracellular space (PubMed:28646141). .
- Expression:
- Highly expressed in skeletal muscle, testis, adrenal gland and thymus, followed by pancreas, liver, heart and thymus. Weakly expressed in kidney, placenta, brain and lung.
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- Antibody-FAQs
- Products Images
- Western blot analysis of lysates from A431 cells, primary antibody was diluted at 1:1000, 4°over night