• Target：
• INT3

• Gene Name：
• INTS3 C1orf193 C1orf60

• Protein Name：
• INT3

• Human Gene Id：
• 65123

• Human Swiss Prot No：
• Q68E01

• Mouse Gene Id：
• 229543

• Mouse Swiss Prot No：
• Q7TPD0

• Immunogen：
• Synthesized peptide derived from human INT3 AA range: 417-467

• Specificity：
• This antibody detects endogenous levels of INT3 at Human/Mouse

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 115kD

• Background：
• The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 small nuclear RNAs. [provided by RefSeq, May 2016],

• Function：
• function:Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.,sequence caution:Intron retention.,similarity:Belongs to the Integrator subunit 3 family.,subunit:Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.,

• Subcellular Location：
• Nucleus . Cytoplasm . Localizes to nuclear foci following DNA damage.

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