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- INT3 rabbit pAb
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INT3 rabbit pAb
- Catalog No.:YT6668
- Applications:WB
- Reactivity:Human;Mouse
- Gene Name:
- INTS3 C1orf193 C1orf60
- Immunogen:
- Synthesized peptide derived from human INT3 AA range: 417-467
- Specificity:
- This antibody detects endogenous levels of INT3 at Human/Mouse
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 115kD
- Background:
- The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 small nuclear RNAs. [provided by RefSeq, May 2016],
- Function:
- function:Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.,sequence caution:Intron retention.,similarity:Belongs to the Integrator subunit 3 family.,subunit:Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.,
- Subcellular Location:
- Nucleus . Cytoplasm . Localizes to nuclear foci following DNA damage.
![](/uploadfiles/PIC/YT6668wb-2019.jpg)
- Western blot analysis of lysates from Hela cells, primary antibody was diluted at 1:1000, 4°over night