CBY1 rabbit pAb
- Catalog No.:YT6597
- Applications:WB
- Reactivity:Human;Mouse;Rat
- Target:
- CBY1
- Fields:
- >>Wnt signaling pathway
- Gene Name:
- CBY1 ARB1 C22orf2 CBY PGEA1 HRIHFB2025
- Protein Name:
- CBY1
- Human Gene Id:
- 25776
- Human Swiss Prot No:
- Q9Y3M2
- Mouse Gene Id:
- 73739
- Mouse Swiss Prot No:
- Q9D1C2
- Rat Gene Id:
- 246768
- Rat Swiss Prot No:
- Q8K4I6
- Immunogen:
- Synthesized peptide derived from human CBY1 AA range: 71-121
- Specificity:
- This antibody detects endogenous levels of CBY1 at Human/Mouse/Rat
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 14kD
- Background:
- Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
- Function:
- function:Inhibits the Wnt/Wingless pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.,miscellaneous:Chibby is Japanese for 'small'; the gene was so named for the RNAi phenotype seen in flies.,similarity:Belongs to the chibby family.,subcellular location:Nuclear, in a punctate manner. Also found in the trans-Golgi.,subunit:Homodimer; interacts with polycystin-2/PKD2 and GM130. Interacts with the C-terminal region of beta-catenin.,tissue specificity:Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Signif
- Subcellular Location:
- Nucleus speckle . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Golgi apparatus. Golgi apparatus, trans-Golgi network .
- Expression:
- Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors.
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- Antibody-FAQs
- Products Images
- Western blot analysis of lysates from KB cells, primary antibody was diluted at 1:1000, 4°over night