• Target：
• PIGZ

• Fields：
• >>Glycosylphosphatidylinositol (GPI)-anchor biosynthesis

• Gene Name：
• PIGZ SMP3

• Protein Name：
• PIGZ

• Human Gene Id：
• 80235

• Human Swiss Prot No：
• Q86VD9

• Mouse Gene Id：
• 239827

• Mouse Swiss Prot No：
• Q8BTP0

• Immunogen：
• Synthesized peptide derived from human PIGZ AA range: 251-301

• Specificity：
• This antibody detects endogenous levels of PIGZ at Human/Mouse

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 64kD

• Background：
• The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors. [provided by RefSeq, Jul 2008],

• Function：
• caution:It is uncertain whether Met-1 or Met-32 is the initiator.,function:Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues.,pathway:Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.,similarity:Belongs to the glycosyltransferase 22 family. PIGZ subfamily.,tissue specificity:Widely expressed at low level, with highest level in brain and colon.,

• Subcellular Location：
• Endoplasmic reticulum membrane ; Multi-pass membrane protein .

• Expression：
• Widely expressed at low level, with highest level in brain and colon.

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